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Dr. Avinash PunshiConsultant Physician · Rheumatologist
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Patient Education

Joint Pain & Autoimmune Diseases

When joint pain is more than ‘wear and tear’ — the specialist evaluation that makes the difference.
On this page
Overview
Symptoms
Causes
Diagnosis
Treatment Options
Lifestyle Advice
FAQs
Related
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Overview

Persistent joint pain, unexplained fatigue, morning stiffness or multi-system symptoms often signal an underlying autoimmune process. A structured rheumatology work-up identifies the specific condition — from spondyloarthritis to Sjögren's, vasculitis or undifferentiated connective tissue disease — and opens the door to targeted, effective treatment.

Symptoms

  • Joint pain lasting more than six weeks
  • Morning stiffness of more than 30 minutes
  • Multiple joints affected symmetrically
  • Fatigue, low-grade fever or unexplained weight loss
  • Dry eyes and mouth, skin rashes or Raynaud's phenomenon

    • Causes

    • Autoimmune conditions such as RA, Lupus, Sjögren's and Vasculitis
    • Spondyloarthritis (Ankylosing Spondylitis, Psoriatic Arthritis)
    • Post-infectious reactive arthritis
    • Overlap syndromes

    Diagnosis

  • Detailed history and full joint examination
  • Complete autoimmune panel (ANA, ENA, ANCA, RF, anti-CCP)
  • Inflammatory markers and complement levels
  • Imaging — ultrasound, X-ray, MRI as required
  • Multidisciplinary referral when other organs are involved

    • Treatment Options

    • Condition-specific DMARDs and biologics
    • Targeted physiotherapy and pain-management strategies
    • Coordinated care with cardiology, nephrology or dermatology as needed
    • Ongoing monitoring for treatment response and side effects

    Lifestyle Advice

  • Do not ignore persistent joint symptoms — early evaluation is critical
  • Keep a symptom diary to help your rheumatologist
  • Stay active within your comfort range
  • Prioritise sleep, nutrition and mental well-being
  • Attend every follow-up — autoimmune disease evolves over time
    • FAQ

    Common questions about Joint Pain & Autoimmune

    Related articles

    Rheumatoid Arthritis

    A chronic autoimmune condition that attacks the joints — treatable, especially when caught early.

    Read the guide

    Lupus (SLE)

    A complex autoimmune disease that requires expert, long-term multi-system care.

    Read the guide

    Osteoarthritis

    The most common form of arthritis — modern care can preserve movement and delay surgery for years.

    Read the guide
    In the consultation

    How this condition is managed in clinic

    A look inside daily practice — explaining diagnoses, reviewing imaging, and guiding patients of every age through their care plan.

    X-RAY REVIEW WITH PATIENT
    JOINT EXAMINATION
    EVIDENCE-BASED COUNSEL
    DEXA BONE-DENSITY REVIEW
    FAMILY CONSULTATION
    ANATOMY WALK-THROUGH

    Ready to feel better?

    Book a consultation with Dr. Avinash Punshi and take the first step toward lasting relief.
    Book Appointment
    Call 0301-2399339
    Dr. Avinash Punshi
    Consultant Physician & Rheumatologist
    Compassionate, evidence-based rheumatology care across Karachi — helping patients live free of joint pain, longer.
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    OPD Timings

    • Doctor Ziauddin Hospital
      Clifton Campus, Block 2
      Mon · Wed · Fri·1:00 – 4:00 PM
      Fees Rs. 2,500
    • Ziauddin Hospital
      Kemari Branch
      Wednesday·12:00 – 2:00 PM
    • Ziauddin Hospital
      North Nazimabad, Block 2
      Tue · Thu · Sat·1:00 – 3:00 PM
      Fees Rs. 2,500
    • Rim Trauma Hospital
      PECHS Block 6, Shahrah-e-Faisal
      Tue · Thu · Sat·4:30 – 6:00 PM
      Fees Rs. 2,000
    • South City Hospital
      Shahrah-e-Firdousi, Clifton
      Tue · Thu·6:30 – 8:30 PM
      Fees Rs. 3,500
    • Islamabad Diagnostic Centre
      Rafiq Plaza, Lucky Star
      Mon · Wed · Fri · Sat·7:30 – 10:00 PM
      Fees Rs. 2,000
    • Islamabad Diagnostic Centre
      Rafiq Plaza, Lucky Star
      Tue · Thu·9:00 – 10:00 PM
      Fees Rs. 2,000
    Saturday appointments are subject to confirmation before your visit.

    Appointments: Mr. Vishal · +92 301 2399339

    © 2026 Dr. Avinash Punshi. All rights reserved.

    Consultant Physician & Rheumatologist · Karachi, Pakistan

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